Endocrine Abstracts

Introduction: Gigantism represents a rare pathology in children, characterized by growth hormone (GH) excess, before epiphyseal fusion. It associates significant morbidity and decreased life expectancy, in lack of appropriate treatment.Case presentation: O.D., a male patient, 16 years old now, has been followed in our clinic since 2016, being diagnosed with gigantism in Bega Pediatric Clinic, at the age of 12 years 9 months. In 2014, the patient presente...

Thyroid-associated ophtalmopathy (TAO) is an organ-specific autoimmune process that is strongly associated with thyroid dysfunction. Patients with TAO may present eyelid retraction, proptosis, chemosis, periorbital oedema and altered ocular motility with significant functional and cosmetic consequences. There is the possibility of coexistence of two or more autoimmune diseases affecting the eye due to the cross-reactivity to common antigens from the eye muscles.<p class="a...

Introduction: Body weight is positively correlated to bone mineral density. The exact mechanism is unclear but gravity may be one of the involved factors. Adipocytokines (leptin and adiponectin), secreted by the adipose tissue, are involved in bone turnover. We investigated the influence of body weight, body composition, and adipocytokines upon bone mass in pre and postmenopausal women.Design: Cross-sectional study including six groups of 8 to 16 healthy...

Introduction: Vitamin D deficiency has been frequently observed in the elderly population. Improving vitamin D status may be an important modifiable risk factor to reduce fractures; however, adherence to daily supplementation is poor. We tested whether oral administration of an alcoholic solution of vitamin D3, 200 000 IU every 4 months in elderly could assure an optimal serum 25(OH)D concentration of 80–120 nmol/l.Method: We enrolled 50 ...

Introduction: The quantitative ultrasound (QUS) is an useful tool in the evaluation of the fragility fracture risk.Aim and study design: We performed the QUS fragility fracture risk groups (valided by the golden standard DXA) by a unifactorial analyze including the bone markers.Method: The cut offs used were: SI≤59U (high risk), SI≥83U (low risk), and medium risk with SI between 59 and 83U. The QUS analyze was performed...

The diagnosis of Cushing’s syndrome, in the clinical practice, requires investigations necessary for distinguishing it from obesity with reactive hypercorticism and for differentiating its forms.The study group was represented by 85 cases of hypercorticism (hospitalized in the Clinic of Endocrinology Timisoara during the period 2000–2009) divided in two groups: obesity with reactive hypercorticism (81.18%) respectively, Cushing’s syndrome ...

Background: Cushing’s syndrome (CS) is associated with a hypercoagulable state and an increased risk for acute coronary syndromes, stroke, and deep vein thrombosis (DVT).Aim: To assess the prevalence of thrombotic events in a series of patients with CS.Patients and methods: Notes of 113 patients with CS were retrospectively reviewed.Results: Instable angina was diagnosed in ten women, aged 52.1±12.2...

Introduction: Osteogenesis Imperfecta (O.I.) is a genetic disorder commonly known as brittle bone disease. The majority of people with O.I. have a mutation in one of two genes, COL 1A1 or COL 1A2, that encode type I collagen. In most families, O.I. is inherited in an autosomal dominant pattern. Dual Energy X-ray Absorptiometry - bone mineral density (DXA-BMD) test provides information about bone quantity, not quality. The bisphosphonates - treatment can minimizing fractures by...

The last decade has provided major progress in the development of highly specific and selective pharmacological agents that have facilitated a more aggressive approach to the treatment of patients with acromegaly. Initial transsphenoidal surgery still appears to be the first line of treatment, but in many cases the biochemical cure targets are not reached and the patient needs adjuvant therapy. Somatostatin analogues have become the mainstay of the medical treatment of acromeg...

Objective: The latest studies on Graves’ ophthalmopathy (GO) emphasize the importance of the orbital adipose tissue and fibroblasts in the pathogenesis of the disease by secreting proinflammatory cytokines. In vitro, these cytokines were proved to have a major role in the maintenance and progress of inflammation in the orbit. The aim of this study was to investigate serum cytokine levels in patients with GO.Materials and methods: Serum interl...